Using Weighted Kaplan-Meier Statistics in Nonparametric Comparisons of Paired Censored Survival Outcomes
نویسندگان
چکیده
منابع مشابه
Using weighted Kaplan-Meier statistics in nonparametric comparisons of paired censored survival outcomes.
This research introduces methods for nonparametric testing of weighted integrated survival differences in the context of paired censored survival designs. The current work extends work done by Pepe and Fleming (1989, Biometrics 45, 497-507), which considered similar test statistics directed toward independent treatment group comparisons. An asymptotic closed-form distribution of the proposed fa...
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A class of statistics based on the integrated weighted difference in Kaplan-Meier estimators is introduced for the two-sample censored data problem. With positive weight functions these statistics are intuitive for and sensitive against the alternative of stochastic ordering. The standard weighted log-rank statistics are not always sensitive against this alternative, particularly if the hazard ...
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This research sequentially monitors paired survival differences using a new class of nonparametric tests based on functionals of standardized paired weighted log-rank (PWLR) and standardized paired weighted Kaplan-Meier (PWKM) tests. During a trial, these tests may alternately assume the role of the more extreme statistic. By monitoring PEMAX, the maximum between the absolute values of the stan...
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Authors' disclosures of potential conflicts of interest are found at the end of this article. S tudies of how patients respond to treatment over time are fundamentally important to understanding how therapies influence quality of life and progression of disease during survi-vorship. When investigators examine change over time in continuous variables (e.g., patient self-reports of pain, fatigue,...
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Calculating summary statistics such as the mean, standard deviation, and an upper confidence limit on the mean is straightforward when the data values are known. However, environmental data often are reported from the analytical laboratory as left censored, meaning the actual concentration for a given contaminant was not detected above the method detection limit. Therefore, the true concentrati...
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ژورنال
عنوان ژورنال: Biometrics
سال: 2001
ISSN: 0006-341X
DOI: 10.1111/j.0006-341x.2001.00361.x